| Engine | kW (hp) | Year |
| CLK 200 Kompressor (209.442) (M 271.940) | 120 (163) | 2003-02…2010-03 |
| CLK 200 CGI (209.343) (M 271.942) | 125 (170) | 2003-07…2010-03 |
| CLK 240 (209.461) (M 112.912) | 125 (170) | 2003-02…2010-03 |
| CLK 320 (209.465) (M 112.955) | 160 (218) | 2003-02…2010-03 |
| CLK 500 (209.475) (M 113.968) | 225 (306) | 2003-02…2010-03 |
| CLK 55 AMG (209.476) (M 113.987) | 270 (367) | 2002-06…2010-03 |
| CLK 350 (209.456) (M 272.960) | 200 (272) | 2005-01…2010-03 |
| CLK 280 (209.454) (M 272.940) | 170 (231) | 2005-01…2010-03 |
| CLK 63 AMG (209.477) (M 156.982) | 354 (481) | 2006-04…2010-03 |
| CLK 320 CDI (209.420) (OM 642.910) | 165 (224) | 2005-03…2010-03 |
| CLK 200 Kompressor (209.441) (M 271.955) | 135 (184) | 2006-10…2010-03 |
| CLK 500 (209.472) (M 273.967) | 285 (388) | 2006-06…2010-03 |
| CLK AMG DTM (209.476) (M 113.994) | 428 (582) | 2004-06…2005-10 |