| Engine | kW (hp) | Year |
| S 500 (217.482) (M 278.929) | 335 (456) | 2015-12…2017-10 |
| AMG S 63 4-matic (217.478) (M 157.985) | 430 (585) | 2015-12…2017-10 |
| AMG S 65 (217.479) (M 279.980) | 463 (630) | 2016-04…2019-05 |
| S 650 Maybach (217.479) (M 279.980) | 463 (630) | 2017-08…2019-05 |
| AMG S 63 4-matic+ (217.488) (M 177.980) | 450 (612) | 2017-10…2020-07 |
| S 560 (217.483) (M 176.980) | 345 (469) | 2017-10…2020-07 |
| AMG S 63 (217.487) (M 177.980) | 450 (612) | 2018-12…2020-07 |